CURRICULUM VITAE
Jonathan D. Dinman, Ph.D.
Tel: (301) 405-0918.
FAX: (301) 314-9489.
email:dinman@umd.edu
Web page: http://dinmanlab.umd.edu/
Undergraduate Education: A.B. Oberlin College, Oberlin, OH. (1980). Department of Philosophy.
Graduate Education: Ph.D, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD. Department of Immunology and Infectious Diseases. (1988). Alan L. Scott, advisor.
Postgraduate Training:
1989 to Postdoctoral Fellow under Dr. Reed Wickner, Section on Genetics of
1992 Simple Eukaryotes, Laboratory of Biochemical Pharmacology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD
1992 to Senior Staff Fellow under Dr. Reed Wickner, Section on Genetics of
1995 Simple Eukaryotes, Laboratory of Biochemical Pharmacology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD
Employment background:
Jan., 2002 – present. Associate Professor, Department of Cell Biology and Molecular Genetics. University of Maryland. College Park, MD. 20742.
July 2006 – present. Affiliate Associate Professor. Department of Chemistry and Biochemistry. University of Maryland. College Park, MD. 20742.
May, 2003 – present. Member, Molecular and Cellular Biology Program. University of Maryland. College Park, MD. 20742.
Jan. 2002 – present. Adjunct Associate Professor, Department of Molecular Genetics and Microbiology. University of Medicine and Dentistry. Piscataway, NJ. 08854.
July, 2001 – Dec., 2001. Associate Professor, Department of Molecular Genetics and Microbiology. University of Medicine and Dentistry. Piscataway, NJ. 08854.
June 1995 – June, 2001. Assistant Professor, Department of Molecular Genetics and Microbiology. University of Medicine and Dentistry. Piscataway, NJ. 08854.
Awards and Honors.
2005. Thomas Alva Edison Patent Award.
2004. University of Maryland College of Life Sciences Faculty Excellence Award for Research.
2004. Outstanding Invention of 2003, Life Sciences. University of Maryland Office of Technology Commercialization, Research and Graduate Studies.
2003. Merck-Frosst Lecture, University of Montreal.
2002. University of Maryland, College of Life Sciences Workstation Deployment Program Faculty Technology Matching Funds Award.
1995–96. American Cancer Society Junior Faculty Research Award
1992–95. National Institutes of Health Staff Fellowship
1989–92. Intramural Research Training Award Fellow, NIH
1989. Fredrick B. Bang Award, Department of Immunology and Infectious Diseases, JHU.
1987–89. Post Certified Scholarship Award, Johns Hopkins University.
1986. Tuition Scholarship Award, Johns Hopkins University.
1984. Sigma Xi Award, Johns Hopkins School of Hygiene and Public Health.
Selected Articles in Refereed Journals (total =53).
Selected articles
Dinman, J.D.*, Ruiz-Echevarria, M.J., Czaplinski, K., and Peltz, S.W. 1997. Peptidyl transferase inhibitors have antiviral properties by altering programmed -1 ribosomal frameshifting efficiencies: development of model systems. Proc. Natl. Acad. Sci. USA 94: 6606-6611.
Hammell, A.B., Taylor, R.L., Peltz, S.W., and Dinman, J.D.* 1999. Identification of putative programmed -1 ribosomal frameshift signals in large DNA databases. Genome Res. 9: 417-427.
Meskauskas, A. and Dinman, J.D.* 2001. Yeast ribosomal protein L5 anchors peptidyl-tRNA to the P-site. RNA 7: 1084-1096.
Dinman, J.D.*, Richter, S., Plant, E.P., Taylor, R., Hammell, A.B., and Rana, T.M.* 2002. The frameshift signal of HIV-1 involves a potential intramolecular triplex RNA structure. Proc. Natl. Acad. Sci. USA 99: 5331-5336.
Harger, J.W., Meskauskas, A., and Dinman, J.D.* 2002. An ‘Integrated Model’ of programmed ribosomal frameshifting and post-transpcriptional surveillance. TiBS 27: 448 – 454. (Invited Review.)
Plant, E.P., Muldoon Jacobs, K.L., Harger, J.W., Meskauskas, A., Jacobs, J.L., Baxter, J.L., Petrov, A.N., and Dinman, J.D.* 2003. The 9Å solution: how mRNA pseudoknots promote efficient programmed –1 ribosomal frameshifting. RNA 9: 168-174.
Meskauskas, A., Baxter, J.L., Carr, E.A., Yasenchak, J., Gallagher, J.E.G., Baserga, S.J., and Dinman, J.D.* 2003. Delayed rRNA processing results in significant ribosome biogenesis and functional defects. Mol. Cell. Biol. 23:1602-1613.
Meskauskas, A., Muldoon Jacobs, K.L., Harger, J.W., and Dinman, J.D.* 2003. Decreased peptidyltransferase activity correlates with increased programmed –1 ribosomal frameshifting and viral maintenance defects in the yeast Saccharomyces cerevisiae. RNA 9: 1019-1024.
Harger, J.W. and Dinman, J.D.* 2003 An in vivo dual-luciferase system for studying translational recoding in the yeast Saccharomyces cerevisiae. RNA 9: 1019-1024.
Plant, E.P., Wang, P., Jacobs, J. L., and Dinman, J.D.* 2004. A programmed -1 ribosomal frameshift signal can function as a cis-acting mRNA destabilizing element. Nucleic Acids Research 32: 784-790.
Jacobs, J.L. and Dinman, J.D.* Systematic analysis of bicistronic reporter assay data. Nucleic Acids Research, 2004; 32:e160-70.
Plant, E.P. and Dinman, J.D.* 2005. Torsional restraint: a new twist on frameshifting pseudoknots. Nucleic Acids Research 33:1825-33.
Plant, E.P., Perez-Alvarado, G, Jacobs, J.L., Mukhopadhyay, B., Hennig, M., and Dinman, J.D.* 2005An three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signal. PLoS Biology 3: 172-184.
Meskauskas, A., and Dinman, J.D.* 2005. Identification of functionally important amino acids of ribosomal protein L3 by saturation mutagenesis. Mol. Cell. Biol., 25: 10863-10874.
Plant, E.P and Dinman, J.D.* 2006. Comparative study of the effects of heptameric slippery site composition on -1 frameshifting among different eukaryotic systems. RNA 12: 666 – 673.
Muldoon-Jacobs, K.L. and Dinman, J.D.* 2006. Specific effects of ribosome-tethered chaperones on programmed -1 ribosomal frameshifting. Eukaryotic Cell 5: 762- 770.
Rakauskaite, R., and Dinman, J.D.* An arc of unpaired “hinge bases” facilitates information exchange among functional centers of the ribosome. Molecular and Cellular Biology 26: 8992 – 9002.
Original Designs, Plans, Inventions, and Patents: 5.
Editorial activities.
Editorial Board, Nucleic Acids Research (Jan. 2007 – Dec. 2009).
Editor-in-Chief, International Journal of Biomedical Science. 2005 – Present.
Reviewing activities for agencies.
National Institutes of Health.
Permanent member, NIH Molecular Genetics C Study Section. Fall 2005 – June 30, 2009. Ad Hoc on various other panels (2000 – present).
National Science Foundation.
Biochemistry of Gene Expression, Eukaryotic Genetics, and Biomolecular Processes (Ad Hoc 1998 – present).
Advising/Research Supervision (since 1996).
12 Undergraduate students; 2 Masters student – M.S. awarded 1999, 2005; 11 Doctoral students. 3 Ph.D. awarded, 6 current; 7 Postdoctoral fellows; 1 Research Associate Professor; 2 Visiting scientists.
Current grant support.
Source: National Institutes of Health. 2 R01 GM58859 01/01/2004 - 12/31/2008
Title: The Biochemistry of Programmed Ribosomal Frameshifting in Yeast
Source: National Institutes of Health. 1 R01 AI064301 07/01/2006 – 06/30/2011
Title: Characterization of the SARS-CoV frameshift signal.